Masaryk University, Masaryk Memorial Cancer Institute
ONCOBIOME
Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response
The project ONCOBIOME seeks to functionally characterize and validate cancer associated gut microbiome fingerprints of high clinical relevance, and to develop diagnosis tools for personalized medicine. The project aims to:   1/ identify and validate core or cancer-specific Gut OncoMicrobiome Signatures (GOMS) associated with cancer occurrence, prognosis and response to therapy or adverse effects  2/ decipher the functional relevance of these cancer-associated gut commensal ecosystems in the regulation of host metabolism, immunity and oncogenesis,   3/ integrate these GOMS with other oncology hallmarks (clinics, genomics, immunomics, metabolomics)   4/ design optimal companion tests, based on those integrated signatures to predict cancer occurrence and progression.