Farmed seafood is a significant source of protein for food with a low-emissions footprint. However, the efficient and cost-effective control of pathogens represents a critical challenge for the sector where there are diverse species and production systems. The EU-funded Cure4Aqua project will improve aquatic animal health and welfare and support environmentally friendly, inclusive, safe and healthy seafood production. Cure4Aqua will engage key stakeholders in developing cost-effective vaccines to prevent disease caused by five pathogens of economic significance to EU aquaculture. Cure4Aqua will identify markers with a diagnostic capacity to integrate into selective breeding programmes and develop innovative, bio-based alternatives to antibiotics solutions for controlling fish pathogens.